Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 65)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0824165	0.0998209	0.4182876
Weighted median	23	-0.0356403	0.0535687	0.5058464
Inverse variance weighted	23	-0.0399268	0.0390158	0.3061418
Simple mode	23	-0.0632395	0.0891797	0.4856948
Weighted mode	23	-0.0391753	0.0633275	0.5425227

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.11849	21	0.8169596
Inverse variance weighted	16.89152	22	0.7693204

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075131	0.0056423	0.1972816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005436	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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