Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 649)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2767403	0.1034738	0.0141888
Weighted median	23	0.1295903	0.0601063	0.0310821
Inverse variance weighted	23	0.0698198	0.0437294	0.1103473
Simple mode	23	0.0907988	0.1138759	0.4337703
Weighted mode	23	0.1442823	0.0629900	0.0319395

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.56616	21	0.3675386
Inverse variance weighted	27.63820	22	0.1879833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0127071	0.0058489	0.0414072

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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