Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 648)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0438458	0.0998208	0.6649708
Weighted median	23	0.0194030	0.0547503	0.7230460
Inverse variance weighted	23	0.0419672	0.0390160	0.2820881
Simple mode	23	0.0409772	0.0858638	0.6379018
Weighted mode	23	0.0234879	0.0588298	0.6935573

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	6.811093	21	0.9984845
Inverse variance weighted	6.811511	22	0.9991788

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001154	0.0056424	0.9838804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0002415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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