Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 647)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0976731	0.1071152	0.3721967
Weighted median	23	-0.0379300	0.0532693	0.4764384
Inverse variance weighted	23	0.0007745	0.0418642	0.9852392
Simple mode	23	-0.0542814	0.0837692	0.5236985
Weighted mode	23	-0.0578696	0.0713474	0.4259988

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.18164	21	0.2843409
Inverse variance weighted	25.32973	22	0.2815681

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0060456	0.0060546	0.3293981

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007675	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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