Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 646)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0543685	0.1096026	0.6250104
Weighted median	23	-0.0650339	0.0600944	0.2791655
Inverse variance weighted	23	-0.0013562	0.0421284	0.9743183
Simple mode	23	0.0251831	0.1125910	0.8250790
Weighted mode	23	-0.0372942	0.0776892	0.6359349

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.31797	21	0.2336552
Inverse variance weighted	25.65088	22	0.2669730

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032555	0.0061953	0.6047555

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007773	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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