Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 645)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2086140	0.1031960	0.0561526
Weighted median	23	0.1287568	0.0559408	0.0213542
Inverse variance weighted	23	0.1195735	0.0402236	0.0029517
Simple mode	23	0.0954480	0.0884266	0.2921003
Weighted mode	23	0.1296608	0.0588942	0.0384795

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.44502	21	0.3742661
Inverse variance weighted	23.38420	22	0.3803143

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005468	0.0058332	0.3592106

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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