Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 643)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0761300	0.1186296	0.5279823
Weighted median	23	0.0241342	0.0555526	0.6639701
Inverse variance weighted	23	0.0146103	0.0460400	0.7509857
Simple mode	23	-0.0731367	0.0965173	0.4566370
Weighted mode	23	0.0242487	0.0590391	0.6852483

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.66000	21	0.0990362
Inverse variance weighted	30.63536	22	0.1038219

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055723	0.0067055	0.4153171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009325	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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