Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 642)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0224155	0.1064722	0.8352841
Weighted median	23	-0.0198313	0.0545710	0.7163033
Inverse variance weighted	23	0.0073756	0.0407478	0.8563628
Simple mode	23	-0.0184824	0.0875261	0.8347026
Weighted mode	23	-0.0258619	0.0636851	0.6885993

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.89189	21	0.2983263
Inverse variance weighted	23.99702	22	0.3473857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018295	0.0060183	0.7641327

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8