Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 641)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0939398	0.1144098	0.4208232
Weighted median	23	0.0204718	0.0625418	0.7434187
Inverse variance weighted	23	0.0173483	0.0448365	0.6988121
Simple mode	23	0.1153085	0.1149858	0.3268574
Weighted mode	23	0.0075150	0.0883683	0.9329971

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58796	21	0.1522287
Inverse variance weighted	29.05510	22	0.1432944

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068343	0.006467	0.3026173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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