Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 640)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0009388	0.1028383	0.9928026
Weighted median	23	-0.0752441	0.0580708	0.1950686
Inverse variance weighted	23	-0.0676436	0.0397328	0.0886687
Simple mode	23	-0.0248859	0.1042771	0.8135849
Weighted mode	23	-0.0920456	0.0762252	0.2400435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.28972	21	0.3829828
Inverse variance weighted	22.81681	22	0.4121348

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040964	0.0058129	0.488742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007824	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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