Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 64)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0777053	0.0998199	0.4449846
Weighted median	23	0.0351234	0.0542348	0.5172321
Inverse variance weighted	23	0.0191342	0.0390155	0.6238318
Simple mode	23	-0.1203011	0.1057648	0.2675913
Weighted mode	23	0.0803235	0.0674906	0.2466746

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.84718	21	0.8760733
Inverse variance weighted	14.25356	22	0.8922360

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035969	0.0056423	0.5307034

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004392	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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