Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 639)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0140402	0.0998206	0.8894831
Weighted median	23	-0.0038300	0.0557040	0.9451838
Inverse variance weighted	23	0.0247730	0.0390156	0.5254609
Simple mode	23	-0.0150329	0.1032787	0.8855971
Weighted mode	23	-0.0413805	0.0777300	0.5998110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.44193	21	0.5568136
Inverse variance weighted	19.62038	22	0.6067726

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023835	0.0056423	0.6770022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006068	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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