Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 638)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0959659	0.0998210	0.3473014
Weighted median	23	-0.0292899	0.0548009	0.5930099
Inverse variance weighted	23	-0.0314880	0.0390158	0.4196328
Simple mode	23	-0.0425351	0.0859691	0.6256657
Weighted mode	23	-0.0186252	0.0683935	0.7879119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.27984	21	0.9317531
Inverse variance weighted	14.20409	22	0.8940777

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0078269	0.0056424	0.1799371

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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