Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 637)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0834886	0.1042784	0.4323101
Weighted median	23	0.0059427	0.0573101	0.9174117
Inverse variance weighted	23	0.0275150	0.0401420	0.4930654
Simple mode	23	0.0197118	0.0956575	0.8386341
Weighted mode	23	0.0129283	0.0677337	0.8503777

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.91748	21	0.3483941
Inverse variance weighted	23.28861	22	0.3855894

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034373	0.0058943	0.5659961

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007207	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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