Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 636)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0895133	0.1118404	0.4324602
Weighted median	23	0.0079042	0.0605477	0.8961353
Inverse variance weighted	23	0.0264063	0.0439793	0.5482229
Simple mode	23	0.0213889	0.0942530	0.8225730
Weighted mode	23	-0.0028546	0.0716240	0.9685675

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.36232	21	0.1929695
Inverse variance weighted	27.95409	22	0.1772078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071186	0.0063217	0.2728486

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000861	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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