Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 635)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1954413	0.0998209	0.0636586
Weighted median	23	-0.0467710	0.0525919	0.3738314
Inverse variance weighted	23	-0.0115147	0.0390158	0.7678947
Simple mode	23	-0.0506902	0.0861899	0.5624393
Weighted mode	23	-0.0561015	0.0598424	0.3586865

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.73618	21	0.8359533
Inverse variance weighted	18.74341	22	0.6611153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0112949	0.0056423	0.0583911

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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