Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 634)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2053449	0.1263996	0.1191701
Weighted median	23	-0.1043520	0.0606641	0.0854034
Inverse variance weighted	23	-0.0146127	0.0512645	0.7756093
Simple mode	23	-0.0776545	0.1181649	0.5178877
Weighted mode	23	-0.1033709	0.0694754	0.1509773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.67357	21	0.0392617
Inverse variance weighted	37.98306	22	0.0184022

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0117129	0.0071448	0.1160313

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011552	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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