Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 633)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0573412	0.1024904	0.5817540
Weighted median	23	0.1031308	0.0589537	0.0802302
Inverse variance weighted	23	0.0579233	0.0391385	0.1388845
Simple mode	23	0.1035173	0.1132545	0.3706139
Weighted mode	23	0.1158617	0.0952051	0.2365102

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.13946	21	0.3915119
Inverse variance weighted	22.13950	22	0.4515891

Test for directional horizontal pleiotropy

egger_intercept	se	pval
3.57e-05	0.0057933	0.9951348

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007377	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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