Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 632)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0027646	0.1140142	0.9808837
Weighted median	23	0.0579914	0.0631830	0.3587071
Inverse variance weighted	23	-0.0012118	0.0435403	0.9777965
Simple mode	23	0.0754138	0.1330393	0.5765521
Weighted mode	23	0.0858686	0.1078830	0.4345710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.39752	21	0.1580796
Inverse variance weighted	27.39939	22	0.1964484

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002442	0.0064447	0.9701327

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008303	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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