Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 631)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0125451	0.1222867	0.9192638
Weighted median	23	0.0404630	0.0564668	0.4736329
Inverse variance weighted	23	0.0086909	0.0467370	0.8524820
Simple mode	23	0.0014528	0.0909741	0.9874024
Weighted mode	23	0.0351246	0.0622921	0.5785465

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.51621	21	0.0654856
Inverse variance weighted	31.56963	22	0.0850352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013041	0.0069122	0.8521668

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009581	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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