Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 630)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1512436	0.0998210	0.1446429
Weighted median	23	0.0534021	0.0552189	0.3334943
Inverse variance weighted	23	0.0377492	0.0390159	0.3332773
Simple mode	23	0.0637405	0.0917603	0.4945514
Weighted mode	23	0.0637405	0.0672745	0.3536920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.47683	21	0.8482596
Inverse variance weighted	16.00265	22	0.8157541

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069697	0.0056424	0.2303824

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005133	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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