Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 63)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1066021	0.1011175	0.3037523
Weighted median	23	-0.0147220	0.0589699	0.8028556
Inverse variance weighted	23	0.0440714	0.0390271	0.2587919
Simple mode	23	-0.0241419	0.1002675	0.8119591
Weighted mode	23	-0.0217694	0.0731905	0.7689245

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.55043	21	0.4258009
Inverse variance weighted	22.01363	22	0.4590755

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038401	0.0057157	0.5090087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007057	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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