Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 629)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0351174	0.1016358	0.7331390
Weighted median	23	-0.0296512	0.0560550	0.5968287
Inverse variance weighted	23	-0.0194053	0.0391245	0.6199021
Simple mode	23	-0.0352188	0.0879083	0.6925556
Weighted mode	23	-0.0221343	0.0689768	0.7513179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.77068	21	0.4128264
Inverse variance weighted	22.12282	22	0.4525786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0033482	0.0057449	0.5662246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006779	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8