Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 628)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0145680	0.0998197	0.8853582
Weighted median	23	0.1190709	0.0530907	0.0249108
Inverse variance weighted	23	0.0939413	0.0390154	0.0160488
Simple mode	23	0.1558741	0.0934590	0.1095217
Weighted mode	23	0.1128666	0.0674092	0.1082210

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.47984	21	0.9526089
Inverse variance weighted	12.22614	22	0.9525313

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048743	0.0056423	0.3974096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005462	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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