Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 627)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1778554	0.0998202	0.0892569
Weighted median	23	0.0489067	0.0572826	0.3932273
Inverse variance weighted	23	0.0169768	0.0390155	0.6634687
Simple mode	23	0.0969255	0.1109726	0.3918695
Weighted mode	23	0.0597242	0.0759618	0.4401137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.01815	21	0.8220402
Inverse variance weighted	18.08405	22	0.7009935

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0098796	0.0056423	0.0945463

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005537	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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