Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 626)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1039731	0.0998198	0.3094375
Weighted median	23	0.0369109	0.0534709	0.4900066
Inverse variance weighted	23	0.0023739	0.0390157	0.9514833
Simple mode	23	0.0024104	0.0929387	0.9795427
Weighted mode	23	0.0304275	0.0639726	0.6390246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.93599	21	0.5892466
Inverse variance weighted	20.15876	22	0.5731094

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062392	0.0056423	0.2813243

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000611	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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