Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 625)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1841654	0.0998202	0.0791927
Weighted median	23	0.0548050	0.0557306	0.3254146
Inverse variance weighted	23	0.0527479	0.0391494	0.1778680
Simple mode	23	0.0453212	0.0892467	0.6166337
Weighted mode	23	0.0653503	0.0631588	0.3120501

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.10534	21	0.5145976
Inverse variance weighted	22.15117	22	0.4508970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080704	0.0056423	0.1673355

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007266	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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