Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 624)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0143056	0.0998211	0.8874099
Weighted median	23	0.0273452	0.0549222	0.6185618
Inverse variance weighted	23	0.0320930	0.0390159	0.4107573
Simple mode	23	0.0076857	0.0835641	0.9275513
Weighted mode	23	0.0099491	0.0703923	0.8888892

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.57648	21	0.7929553
Inverse variance weighted	15.83149	22	0.8241602

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028493	0.0056424	0.6188256

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005002	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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