Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 623)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0550425	0.1193187	0.6493211
Weighted median	23	0.0379148	0.0642636	0.5551984
Inverse variance weighted	23	0.0279648	0.0461803	0.5448083
Simple mode	23	0.0184263	0.1202734	0.8796340
Weighted mode	23	0.0219882	0.0822736	0.7917610

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.00612	21	0.0918651
Inverse variance weighted	30.82234	22	0.0998086

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0050975	0.0067445	0.4581628

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009495	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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