Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 622)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0045582	0.0998210	0.9640095
Weighted median	23	0.0045627	0.0581995	0.9375124
Inverse variance weighted	23	-0.0071338	0.0390157	0.8549207
Simple mode	23	-0.0355191	0.1005208	0.7271892
Weighted mode	23	0.0010177	0.0718293	0.9888238

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.07547	21	0.5802987
Inverse variance weighted	19.09166	22	0.6396616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000718	0.0056424	0.8999512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005796	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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