Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 621)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0344805	0.0998209	0.7332122
Weighted median	23	-0.0002418	0.0544884	0.9964590
Inverse variance weighted	23	0.0076276	0.0390158	0.8450006
Simple mode	23	-0.0536841	0.1002765	0.5977710
Weighted mode	23	-0.0009302	0.0653285	0.9887683

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.48730	21	0.7977309
Inverse variance weighted	15.69733	22	0.8306182

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025859	0.0056424	0.6514491

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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