Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 620)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1451648	0.1042175	0.1782212
Weighted median	23	0.0299373	0.0622868	0.6307752
Inverse variance weighted	23	0.0014934	0.0419541	0.9716035
Simple mode	23	0.0537308	0.1446477	0.7138483
Weighted mode	23	0.1156938	0.1539206	0.4602300

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.89179	21	0.3497748
Inverse variance weighted	25.43974	22	0.2765114

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090064	0.0058909	0.1412253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007709	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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