Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 62)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0726102	0.0998201	0.4750067
Weighted median	23	-0.0254353	0.0558128	0.6485869
Inverse variance weighted	23	-0.0601313	0.0397633	0.1304752
Simple mode	23	-0.0414722	0.0821600	0.6187367
Weighted mode	23	-0.0197681	0.0582349	0.7374871

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.76387	21	0.4734435
Inverse variance weighted	22.85113	22	0.4101761

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081516	0.0056423	0.1632888

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007644	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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