Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 619)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0213281	0.1088577	0.8465512
Weighted median	23	-0.0290448	0.0558824	0.6032383
Inverse variance weighted	23	-0.0149920	0.0416994	0.7192018
Simple mode	23	-0.0590145	0.0904273	0.5207646
Weighted mode	23	-0.0416268	0.0620036	0.5089792

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.97448	21	0.2482711
Inverse variance weighted	25.13074	22	0.2908634

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022304	0.0061531	0.7206137

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000766	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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