Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 618)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0598512	0.1013535	0.5611447
Weighted median	23	-0.0799879	0.0543216	0.1408891
Inverse variance weighted	23	-0.0679108	0.0390155	0.0817516
Simple mode	23	-0.0023436	0.0923011	0.9799720
Weighted mode	23	-0.0748407	0.0577599	0.2085019

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.65027	21	0.4198979
Inverse variance weighted	21.65796	22	0.4804559

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004949	0.005729	0.9319731

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007481	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8