Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 617)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0874927	0.1381070	0.5332377
Weighted median	23	-0.0063671	0.0640156	0.9207722
Inverse variance weighted	23	-0.0142265	0.0535368	0.7904454
Simple mode	23	-0.2020790	0.1193576	0.1045598
Weighted mode	23	-0.0729266	0.0776977	0.3581306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.19914	21	0.0070328
Inverse variance weighted	41.42480	22	0.0073324

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062465	0.0078064	0.4325675

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012593	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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