Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 616)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1013719	0.0998209	0.3214076
Weighted median	23	0.0086927	0.0556202	0.8758070
Inverse variance weighted	23	0.0200780	0.0390156	0.6068220
Simple mode	23	0.0438472	0.0886068	0.6256112
Weighted mode	23	0.0104582	0.0655052	0.8746102

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.54891	21	0.6773438
Inverse variance weighted	19.29614	22	0.6269773

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074582	0.0056424	0.2004447

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005927	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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