Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 615)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1191449	0.0998199	0.2459454
Weighted median	23	-0.0836115	0.0556080	0.1326877
Inverse variance weighted	23	-0.0664710	0.0390154	0.0884349
Simple mode	23	-0.0554150	0.1031819	0.5966160
Weighted mode	23	-0.0974212	0.0649449	0.1478144

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.13325	21	0.9601286
Inverse variance weighted	11.46192	22	0.9675186

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032347	0.0056423	0.5725345

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004353	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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