Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 614)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0734225	0.1509080	0.6316249
Weighted median	23	-0.0492803	0.0610917	0.4198613
Inverse variance weighted	23	0.0055956	0.0580695	0.9232343
Simple mode	23	-0.0156152	0.1150977	0.8933163
Weighted mode	23	-0.0337754	0.0675324	0.6219453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.99642	21	0.0006884
Inverse variance weighted	48.73605	22	0.0008666

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048525	0.00853	0.5754785

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014773	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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