Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 613)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2440404	0.0998174	0.0233955
Weighted median	23	0.0785288	0.0580631	0.1762237
Inverse variance weighted	23	0.0716942	0.0390149	0.0661200
Simple mode	23	0.0800060	0.0955149	0.4112473
Weighted mode	23	0.0610653	0.0848078	0.4790790

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.59625	21	0.7352709
Inverse variance weighted	20.11503	22	0.5758446

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0105839	0.0056422	0.0746482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007118	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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