Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 612)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0408014	0.1186226	0.7342964
Weighted median	23	0.0316368	0.0579314	0.5849912
Inverse variance weighted	23	-0.0123125	0.0455527	0.7869363
Simple mode	23	0.0507141	0.0917177	0.5858822
Weighted mode	23	0.0547854	0.0623951	0.3894109

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.65608	21	0.0991199
Inverse variance weighted	29.99026	22	0.1187013

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032617	0.0067051	0.6316848

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009118	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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