Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 611)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0729937	0.1230234	0.5592958
Weighted median	23	-0.1395984	0.0606064	0.0212586
Inverse variance weighted	23	-0.0849065	0.0469915	0.0707856
Simple mode	23	-0.1690542	0.1138375	0.1517200
Weighted mode	23	-0.1153292	0.0733402	0.1301015

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.89828	21	0.0599529
Inverse variance weighted	31.91509	22	0.0788552

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007316	0.0069539	0.9172134

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011106	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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