Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 610)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1545938	0.0998194	0.1363851
Weighted median	23	-0.0281372	0.0569470	0.6212397
Inverse variance weighted	23	-0.0081635	0.0390155	0.8342626
Simple mode	23	0.0713467	0.1115542	0.5290569
Weighted mode	23	-0.0659604	0.0800943	0.4190427

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.07036	21	0.7068321
Inverse variance weighted	19.61035	22	0.6073988

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0089923	0.0056423	0.1259368

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005956	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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