Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 61)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0091310	0.1176069	0.9388494
Weighted median	23	0.0317980	0.0551191	0.5640102
Inverse variance weighted	23	-0.0257705	0.0450219	0.5670511
Simple mode	23	-0.0413221	0.0942653	0.6653997
Weighted mode	23	0.0042547	0.0624604	0.9463065

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.15065	21	0.1104315
Inverse variance weighted	29.29494	22	0.1366312

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021433	0.0066477	0.7503282

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009009	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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