Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 609)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0599270	0.0998211	0.5547010
Weighted median	23	0.0407344	0.0540904	0.4514016
Inverse variance weighted	23	0.0703922	0.0396101	0.0755471
Simple mode	23	0.0601923	0.0890174	0.5059695
Weighted mode	23	0.0397452	0.0583962	0.5032174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.66376	21	0.4796360
Inverse variance weighted	22.67549	22	0.4202431

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080029	0.0056424	0.1707574

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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