Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 608)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0551829	0.0998204	0.5862223
Weighted median	23	0.0338274	0.0534457	0.5267792
Inverse variance weighted	23	0.0497876	0.0390155	0.2019204
Simple mode	23	0.0399350	0.0949313	0.6780753
Weighted mode	23	0.0766447	0.0666268	0.2623471

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.26362	21	0.9322259
Inverse variance weighted	12.26707	22	0.9516155

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0003313	0.0056423	0.9537292

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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