Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 607)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0114524	0.0998210	0.9097496
Weighted median	23	-0.0295495	0.0554227	0.5939190
Inverse variance weighted	23	-0.0634835	0.0390156	0.1037093
Simple mode	23	-0.0262671	0.0866303	0.7645792
Weighted mode	23	-0.0352268	0.0632907	0.5834277

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.66856	21	0.6063925
Inverse variance weighted	18.98924	22	0.6459927

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031952	0.0056424	0.5771983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006556	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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