Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 606)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2287917	0.0998187	0.0323343
Weighted median	23	0.0948862	0.0617020	0.1240939
Inverse variance weighted	23	0.0304339	0.0393922	0.4397673
Simple mode	23	0.1240425	0.1093105	0.2686841
Weighted mode	23	0.1355347	0.0799248	0.1040355

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.76629	21	0.6637421
Inverse variance weighted	22.42724	22	0.4346487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0121812	0.0056423	0.0425781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000698	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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