Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 605)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0197701	0.1227406	0.8735758
Weighted median	23	-0.0227270	0.0556528	0.6830015
Inverse variance weighted	23	0.0169440	0.0468724	0.7177308
Simple mode	23	-0.0017982	0.0897155	0.9841896
Weighted mode	23	0.0058695	0.0634163	0.9270943

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.75152	21	0.0620282
Inverse variance weighted	31.75246	22	0.0817153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001735	0.0069378	0.9802793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009678	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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