Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 604)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0122319	0.0998204	0.9036376
Weighted median	23	0.0540875	0.0555682	0.3303782
Inverse variance weighted	23	0.0553664	0.0390157	0.1558762
Simple mode	23	0.0402670	0.0933984	0.6705680
Weighted mode	23	0.0436963	0.0653760	0.5108408

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.75262	21	0.6010059
Inverse variance weighted	19.29391	22	0.6271161

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041512	0.0056423	0.4700362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8